In-House DNA Engineering Service

Instead of investing time performing your own DNA manipulations, let us do the work for you. We can do any job with low- or high-copy plasmids, BACs, and the E.coli chromosome.

Animal / Mouse model

• Conditional knock-out
  e.g. to analyse the function of a gene
• Exchange of exons
  e.g. to humanize the animal model
• Point mutations
  e.g. to analyse the effect of SNPs
• Reporter fusions
  e.g. to analyse the expression pattern of a gene
• Promoter fusions
  e.g expression of a cDNA from a tissue specific promoter
• Fusion proteins
  e.g. SNAP-tag for detection, localisation and affinity purification

Modifications of the E.coli chromosome

• Knock-out / interruption of chromosomal genes
• Knock-out / removal of chromosomal genes
• Exchange of chromosomal genes
• Replacement of a chromosomal promoter

You provide the name of the gene to be targeted, we supply the targeting vector according to your specifications. Please contact our DNA Engineering department, at contact@genebridges.com for further information.